DR. JUAN PABLO DE RIVERO VACCARI
My laboratory focuses on studying the therapeutic potential and molecular mechanisms underlying the innate immune response in the central nervous system due to injury and disease.
Schematic of Inflammasome Activation in the CNS. Upon activation the inflammasome triggers inflammation and pyroptotic cell death that is dependent on the formation of ASC filaments/specks. de Rivero Vaccari JP, Dietrich WD, Keane RW. Transl Res. 2015 May 12. Review.
Inflammasome proteins are released in exosomes after CNS injury. CNS trauma induces inflammasome activation in the nervous system and secretion of exosomes containing inflammasome protein cargo into cerebral spinal fluid. The inflammasome containing exosomes then fuse with target cells to activate the innate immune response in peripheral tissues. de Rivero Vaccari JP, Brand F 3rd, Adamczak S, Lee SW, Barcena JP, Wang MY, Bullock MR, Dietrich WD, Keane RW.J Neurochem. 2015 Jan 27.